Involvement of Brca1 in S-Phase and G 2 -Phase Checkpoints after Ionizing Irradiation
نویسندگان
چکیده
منابع مشابه
Phosphorylation of serine 1387 in Brca1 is specifically required for the Atm-mediated S-phase checkpoint after ionizing irradiation.
Although it is well established that inheritance of mutations in the Brca1 gene significantly increases the chances of developing breast or ovarian cancers, the mechanisms underlying this specific tumor susceptibility remain to be clarified. It is clear that one of the roles of the Brca1 protein is to facilitate cellular responses to DNA damage. We recently reported that Brca1 function is requi...
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SET8 is degraded via PCNA-coupled CRL4(CDT2) ubiquitylation in S phase and after UV irradiation
The eukaryotic cell cycle is regulated by multiple ubiquitin-mediated events, such as the timely destruction of cyclins and replication licensing factors. The histone H4 methyltransferase SET8 (Pr-Set7) is required for chromosome compaction in mitosis and for maintenance of genome integrity. In this study, we show that SET8 is targeted for degradation during S phase by the CRL4(CDT2) ubiquitin ...
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Background: The fallopian tube serves as optimal environment for the transport of gamets , fertilization and early development of embryo./In this study, the morphological assessment of superovulated mice fallopian tube were investigated at window implantation period Materials and Methods: Female mice were superovualated then were mated with vasectomized mice; the mice were divided in experiment...
متن کاملDifferential S-phase progression after irradiation of p53 functional versus non-functional tumour cells
BACKGROUND Many pathways seem to be involved in the regulation of the intra-S-phase checkpoint after exposure to ionizing radiation, but the role of p53 has proven to be rather elusive. Here we have a closer look at the progression of irradiated cells through S-phase in dependence of their p53 status. MATERIALS AND METHODS Three pairs of tumour cell lines were used, each consisting of one p53...
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ژورنال
عنوان ژورنال: Molecular and Cellular Biology
سال: 2001
ISSN: 0270-7306,1098-5549
DOI: 10.1128/mcb.21.10.3445-3450.2001